CME INFORMATION

FACULTY AFFILIATIONS AND DISCLOSURES

Case Studies

Case 1 from the practice of Malek Safa, MD: A 58-year-old man with a 15 pack-year smoking history who presented with a 3-cm nonsquamous-cell non-small cell lung cancer (NSCLC) and a single suspicious 2-cm adrenal mass. The patient was treated with preoperative carboplatin/paclitaxel and bevacizumab, but subsequent MRI revealed three new brain lesions (presented to Dr Socinski).

Case 2 from the practice of Charles M Farber, MD, PhD: A 69-year-old man and former oligosmoker with extensive, painful bony metastases and liver metastases from NSCLC. The patient was started on zoledronic acid and was treated with carboplatin/paclitaxel and bevacizumab/erlotinib (presented to Dr Socinski).

Case 3 from the practice of Steven P Kanner, MD: An 80-year-old woman and nonsmoker with Stage IV NSCLC who had a five-year response to an EGFR TKI and was treated with pemetrexed after disease progression (presented to Dr Socinski).

Case 4 from the practice of Isaac Levy, MD: An 80-year-old man and former smoker with good performance status was diagnosed with Stage IIIB squamous-cell NSCLC. The patient was treated with carboplatin/docetaxel and concurrent radiation therapy, but due to poor patient tolerance, the radiation therapy was discontinued and he received only two total cycles of chemotherapy, with nanoparticle albumin-bound (nab) paclitaxel substituted for docetaxel in the second cycle. He ended up having a CR after this abbreviated treatment course but then experienced rapid local recurrence off treatment (presented to Dr Lilenbaum).

Case 5 from the practice of Kenneth R Hoffman, MD, MPH: An 88-year-old oligosmoker who presented with a traumatic hip fracture was incidentally found to have a 6-cm right lung mass without evidence of metastatic disease, in addition to sick sinus syndrome. He underwent pacemaker implantation and total hip replacement, followed one month later by right lower lobe lobectomy, all of which he tolerated well. His lung pathology revealed a moderately differentiated, pathologic Stage IIB (T2N1M0) adenocarcinoma (presented to Dr Lilenbaum).

Case 6 from the practice of Charles A Henderson, MD: A 54-year-old physician and former smoker presented with de novo brain-only metastases from large-cell carcinoma of the lung. He has no evidence of disease 10+ years after treatment with whole-brain radiation therapy followed by systemic treatment with carboplatin/ paclitaxel (presented to Dr Kim).

Case 7 from the practice of Atif M Hussein, MD: A 61-year-old man with malignant pleural mesothelioma was treated with neoadjuvant platinum chemotherapy and pemetrexed, pneumonectomy and radiation therapy but soon thereafter developed peritoneal disease (presented to Dr Kim).

Case 8 from the practice of Dr Hoffman: A 67-year-old man with a recent myocardial infarction presented with a Stage IIA adenocarcinoma 10 years after resection for a contralateral T1N0M0 large-cell carcinoma and 33 years after radiation therapy for Hodgkin disease to the site of his current disease (presented to Dr Kim).