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Meet The Professors: A case-based discussion on the management of colorectal cancer in the adjuvant and metastatic settings

OVERVIEW OF ACTIVITY

Colorectal cancer is among the most common types of cancer in the United States, and the arena of colorectal cancer treatment continues to evolve. Published results from ongoing clinical trials lead to the emergence of new therapeutic agents and regimens and changes in indications, doses and schedules for existing treatments. In order to offer optimal patient care — including the option of clinical trial participation — the practicing medical oncologist must be well informed of these advances. In order to incorporate research advances into developing treatment strategies for patients, the CME program Meet The Professors uses case-based discussions between community oncologists and clinical investigators.

LEARNING OBJECTIVES

• Compare and contrast the incremental benefit and risk of adjuvant chemotherapy for patients with Stage II versus Stage III colon cancer.
• Assess the current availability and value of K-ras testing to select patients with colorectal cancer (CRC) who may benefit from treatment with EGFR inhibitors.
• Communicate the clinical rationale for combination regimens, sequential single-agent strategies and chemotherapy-free intervals when recommending treatment for patients with recurrent or de novo advanced CRC.
• Develop an evidence-based algorithm for the treatment of metastatic CRC that incorporates the individualized use of biologic agents, based on an understanding of the efficacy and tolerability of these therapies.
• Identify appropriate treatment strategies for elderly patients with CRC that minimize therapy-induced toxicity and preserve quality of life.
• Recognize the clinical characteristics of patients with Stage IV CRC who may be candidates for metastectomy with curative intent.
• Discern the clinical utility of neoadjuvant or perioperative chemotherapy to facilitate surgical resection and reduce the risk of recurrence for patients with CRC and isolated hepatic metastases.
• Counsel appropriately selected patients about the availability of ongoing clinical trials in which they may be eligible to participate.

ACCREDITATION STATEMENT

Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

CREDIT DESIGNATION STATEMENT

Research To Practice designates this educational activity for a maximum of 2.75 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

HOW TO USE THIS CME ACTIVITY

This CME activity contains an audio component. To receive credit, the participant should review the CME information, listen to the CDs and complete the Educational Assessment and Credit Form located in website at ResearchToPractice.com/MTP/Colorectal.

This program is supported by educational grants from Genentech BioOncology and ImClone Systems Incorporated.