Table of Contents
  CME Information
  Faculty Affiliations; Content Validation and Disclosures;
Medical Oncologist Community Panel
  Editor’s Note:
When to pull the trigger
Neil Love, MD
   
CASE 1:

A 40-year-old woman with a palpable, high-grade, ER/PR-negative, strongly HER2-
positive invasive ductal carcinoma with four separate tumors at mastectomy and 2/19
positive nodes (from the practice of Dr Barbara G Fallon)
CASE 2:
A 46-year-old perimenopausal woman with a 1.4-centimeter, Grade II, three-nodepositive, ER-positive/PR-negative, HER2-positive infiltrating ductal carcinoma who
was accepted to the Intergroup adjuvant trastuzumab trial (from the practice of Dr
Frederick P Smith)
CASE 3:
 A 45-year-old woman who presented in 1999 with ER/PR-positive, HER2-negative,
node-negative bilateral breast tumors (right: 2.4 centimeters; left: 1.2 centimeters).
After bilateral mastectomy, AC chemotherapy and five years of tamoxifen, she
presented in 2005 with extensive ER/PR-negative, HER2-negative metastatic disease
(from the practice of Dr Paul K Marcom).
CASE 4:
A 38-year-old woman with a 1.5-centimeter, poorly differentiated, ER-positive/PRnegative, HER2-negative intraductal breast tumor with vascular invasion and four positive nodes (from the practice of Dr Doron Weiner)
CASE 5:
 A 70-year-old woman with a 2.5-centimeter, Stage II, ER/PR-positive, HER2-negative
adenocarcinoma with two positive nodes (from the practice of Dr Robert Goldberg)
CASE 6:
 A 55-year-old woman who presented with a locally advanced ER/PR-positive left
breast tumor and bone metastases (from the practice of Dr Leon H Dragon)
CASE 7: A 68-year-old woman who presented in 1997 with a four-centimeter, node-negative,
ER-positive intraductal carcinoma with a small focus of microinvasion. One year later
she developed and was treated for a fallopian tube carcinoma. In 2002, she had an
ER-positive chest wall recurrence (from the practice of Dr William G Reeves)
CASE 8: A 77-year-old woman diagnosed with a 3.5-centimeter, Grade III ER/PR-negative,
HER2-positive infiltrating ductal carcinoma one year after undergoing MRM for a Grade
III DCIS (from the practice of Dr Gary A Steinecker)


2005 VOL 3, ISSUE 6

EDITOR
Neil Love, MD

FACULTY
Aman U Buzdar, MD
Kevin R Fox, MD
Gershon Locker, MD
Eric P Winer, MD


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